Regesi
* PRODUCT NAME:
• Regesi
* INCI NAME:
• Calcium Phosphate Silicate
*ORIGIN:
• China
* INTRODUCTION:
• RegeSi (Regenerative Silicon) is a breakthrough next-generation bio-regenerative ingredient designed to promote in-situ tissue repair by activating the body’s natural biological regeneration process.
• Unlike traditional ingredients that only provide covering or protective functions, RegeSi actively interacts biologically to stimulate regeneration from the cellular level to tissue reconstruction.
• RegeSi is a proud innovation developed by PhD researchers from Tsinghua University, awarded the China Silver Patent Award and recognized as a leading product under the national standard (GB/T 45893-2025). It has been widely applied in both civilian and military medicine for the treatment of deep and extensive wounds.
* CORE TECHNOLOGY:
• Self-assembled microemulsion technology enables silicon, calcium, and phosphorus components to be uniformly distributed at the nanoscale, enhancing cellular interaction and optimizing regenerative performance.
• 3D porous nanostructure (4–50 nm) with an extremely large surface area (180–576 m²/g), approximately 172 times greater than conventional materials, provides an ideal environment for cell adhesion and new tissue formation. The interconnected porous structure facilitates oxygen and nutrient transport, accelerating tissue recovery.
• Organic calcium technology enhances calcium ion release to stimulate bone and tissue regeneration while improving biocompatibility.
• Pre-mineralization treatment creates a pre-formed bioactive mineral layer on the surface, allowing faster cellular integration and accelerating the regeneration of bone, teeth, and damaged tissues.
• Controlled ion-release mechanism maintains Ca²⁺ and Si⁴⁺ concentrations within a safe range, promoting tissue regeneration while ensuring excellent biological safety.
* BENEFITS:
1. DEEP WOUND HEALING WITH MINIMAL SCARRING
MECHANISM:
RegeS supports all 4 stages of the wound-healing process:
• Hemostasis: Releases Ca²⁺ ions to promote thrombin formation, while the 3D structure retains blood components for rapid clotting.
• Anti-inflammation: Promotes macrophage transition from M1 (pro-inflammatory) to M2 (regenerative), shortening the inflammatory phase and creating an optimal healing environment.
• Proliferation: Stimulates angiogenesis and extracellular matrix (ECM) synthesis while promoting growth factor secretion (VEGF, TGF-β).
• Remodeling: Inhibits excessive fibroblast differentiation and reduces excessive collagen deposition, helping prevent scar formation.
RESULTS:
From Day 0 to Day 11, the RegeSi-treated group demonstrated significantly faster wound healing compared to the control group.
=> RegeSi accelerated wound healing by more than 40%, supporting vascular regeneration, nerve repair, and skin structure recovery with minimal scar formation.
2. ORAL CARE
MECHANISM:
• Remineralization: Releases Ca²⁺ and PO₄³⁻ ions to form a natural hydroxyapatite layer integrated into tooth enamel, restoring tooth structure.
• Dentinal tubule sealing: Nano-sized particles penetrate dentinal tubules and form a dense mineral layer that seals the tubules, helping block external stimuli that cause tooth sensitivity.
• Chemical bonding: RegeSi forms durable chemical bonds with both enamel and dentin, ensuring long-lasting restorative effects.
RESULTS:
• Sealed up to 99.72% of dentinal tubules after 48 hours.
• Increased enamel hardness.
• Delivered rapid and long-lasting sensitivity relief.
• Helped reduce plaque formation and improve gum health.
=> RegeSi demonstrated effective gingivitis recovery in a mouse model. Results showed significant inflammation reduction and rapid gum tissue recovery from Day 1 to Day 5, while the control group still exhibited inflammation and slower recovery.
* APPLICATIONS & RECOMMENDED USE LEVEL:
• Oral care products (enamel regeneration and protection, prevention of gum recession, dental caries, mouth ulcers, etc.)
• Scar treatment gels and wound-healing products (bite/scratch wounds, post-cesarean wounds, post-cosmetic surgery wounds)
+ Oral care: 5%-20%
+ Wound healing: >15%
* MARKETING POINT:
• Accelerates wound healing by >40% while minimizing scar formation.
• Seals 99.72% of dentinal tubules after 48 hours for rapid sensitivity relief.
• Simultaneously regenerates soft and hard tissues, enabling multifunctional applications (Skin, Oral, Medical).
• 3D nano-porous structure with a surface area 172 times larger than conventional materials and biological activity 84 times higher.
• Excellent biological safety (~99% cell viability).
• Strong scientific foundation with 76+ patents and SCI publications.
