Burgeon-up

PRODUCT NAME:
• Burgeon-up

INCI NAME:
• Water, Alcohol, Nasturtium Officinale Leaf/Stem Extract

WEIGHT:
• 5kg

ORIGIN:
• Japan

INTRODUCTION:
• Focus on “R-spondin 1” which activates the outer root sheath, the foundation of hair follicles
• “R-spondin 1” is a protein involved in the regeneration of organs and tissue and is currently increasing attention in the field of regenerative medicine. In the field of hair science, “R-spondin 1” activates the foundation of hair follicles, known as the outer root sheath, which is important in making thick hairs that do not come out easily. This led to the development of “BURGEON-UP” which is the hair growth material applied for the first time.
• As “BURGEON-UP” also suppresses the mechanism of action of male hormones, it activates follicles while also preventing hair loss. In addition to male hair loss, “BURGEON-UP” is expected to work on female hair loss.

DESCRIPTION: Light yellow to yellow liquid, having slightly characteristic odor

RECOMMENDED BLENDING AMOUNT: 2%

FUNCTIONS:
1. Promoting the secretion of R-spondin 1
• 0.5% and 1% BURGEON-UP was added to cultured human dermal papilla cells, culture supernatant was collected 2 days later, and R-spondin 1 protein content was measured using ELISA.
• BURGEON-UP was shown to Increase the R-spondin 1 secretion and activate outer root sheath cells.

2. Suppressing the secretion of hair loss factor DKK 1
• 0.25% and 0.5% BURGEON-UP were added to cultured human dermal papilla cells in the presence of DHT, the culture supernatant was collected 3 days later, and the DKK 1 protein amount was measured using ELISA.
• BURGEON-UP was shown to suppress the DKK 1 secretion in dermal papilla cells and prevent hair loss caused by male hormones.

3. Human hair follicle elongation
• Hair follicles with surrounded tissues were collected from the female subject and the organs culture was carried out. Hair follicles were cultured in a medium containing 1% BURGEON-UP for 5 days, and the length of hair follicle was measured.
• BURGEON-UP was confirmed to have the effect of elongating human hair follicle tissues.

4. Hair growth in clinical trials
• A lotion containing 2% BURGEON-UP or a control lotion was applied to the head of 40 male test subjects aged between 20 and 55 living in India twice a day for 6 months. Their hair condition was measured using TrichoScan. Total hair number, hair growth rate and hair thickness were significantly increased in the area of BURGEON-UP applied.