Delentigo™
Delentigo™ – A Specialized Solution for Age Spots and Uneven Skin Tone
1. What is Delentigo™?
✔ Delentigo™ is a cosmetic ingredient designed to improve age spots and uneven skin tone through a dual approach targeting both Melanin and Lipofuscin.
✔ Delentigo™ combines two key active components:
• Organic Swiss garden cress sprout extract
• Soy-derived genistein in aglycone form
✔ These components are incorporated into a delivery system that provides time-released activity.
✔ Product Information
• Product Name: Delentigo™
• INCI Name: Lepidium Sativum Sprout Extract (and) Lecithin (and) Soy Isoflavones (and) Polysorbate 80 (and) Alcohol (and) Glycerin (and) Phenoxyethanol (and) Aqua/Water
• Recommended Use Level: 1–4%
• Origin: Switzerland
• Packing: 1 kg
2. Key Active Components of Delentigo™
✔ Organic Swiss Garden Cress Sprout Extract
• Garden cress sprout extract is rich in glucosinolates – phytonutrients capable of neutralizing reactive oxidants.
• According to the technical documentation, this component is described as a “second-generation” antioxidant due to its ability to stimulate the cells’ own antioxidant system.
✔ In addition, garden cress sprout extract can:
• Stimulate proteasome activity
• Inhibit α-MSH-induced melanin synthesis
✔ Soy-Derived Genistein in Aglycone Form
• Genistein is one of the most abundant isoflavones found in soy.
✔ In Delentigo™, Genistein offers the following properties:
• Supports anti-aging activity by promoting collagen
• Antioxidant activity
• Anti-inflammatory activity
• Inhibition of tyrosine kinase
✔ The combination of garden cress sprout extract and Genistein forms the active foundation of Delentigo™ for formulations targeting age-related pigmentation.
3. How Does Delentigo™ Target Melanin and Lipofuscin?
One of the key features of Delentigo™ is its dual action targeting both Melanin and Lipofuscin.✔ Melanin – A Pigment Associated with Age Spots
• Under UV exposure, keratinocytes produce signaling molecules including α-MSH, Endothelin-1 (ET-1), and Stem Cell Factor (SCF).
• α-MSH activates melanocytes, while SCF and ET-1 stimulate melanocyte development, melanin production, and dendrite formation.
• Higher concentrations of SCF and ET-1 are found in age spot areas, resulting in increased melanin production.
• The garden cress sprout extract in Delentigo™ can inhibit α-MSH-induced melanin synthesis.
✔ Lipofuscin – The “Aging Pigment”
• Lipofuscin is involved in the formation of age spots and is associated with the proteasome – the cell’s protein degradation system.
• Proteasome activity declines with age, while UV exposure can also impair the function of this system.
• The garden cress sprout extract in Delentigo™ can stimulate proteasome activity.
=> By targeting both Melanin and Lipofuscin, Delentigo™ provides a dual-action approach to age spots.
4. Key Benefits and Efficacy of Delentigo™
4.1 Stimulates Proteasome Activity
✔ The ability of garden cress sprout extract to stimulate proteasome activity was evaluated using the Proteasome-Glo™ Assay.
✔ According to the test results:
• At 0.11% Cress Sprout Extract (CSE), proteasome activity in aged fibroblasts reached a level comparable to that of young fibroblasts.
• At 0.33% CSE, proteasome activity increased by 70%.
✔ These results demonstrate that garden cress sprout extract can significantly stimulate proteasome activity in aged fibroblasts.
4.2 Selectively Reduces the Appearance of Age Spots
✔ Delentigo™ was evaluated in an in vivo study for its ability to improve the appearance of age spots.
✔ A 4-week study using a cream containing 4% Delentigo™ showed a visible reduction in age spots, while having no significant effect on normally pigmented surrounding skin.
=> Selective brightening effect on targeted skin areas.
4.3 Promotes a More Even Skin Tone
✔ The efficacy of Delentigo™ was further evaluated over a longer period of use.
✔ After 8 weeks of using a cream containing 4% Delentigo™ twice daily, the pigmentation difference between age spots and normally pigmented surrounding skin was reduced by approximately 50%.
=> These results indicate that Delentigo™ helps reduce the contrast between age spots and the surrounding skin, promoting a more even-looking skin tone.
5. Key Benefits of Delentigo™
✔ Helps promote a more even skin tone
✔ Visibly reduces age-related pigmentation spots
✔ Helps protect against signs of photoaging and dark spots
✔ Provides selective brightening effects on targeted skin areas
✔ Provides time-released activity through an advanced delivery system
=> These properties make Delentigo™ suitable for skincare products targeting age spots, hyperpigmentation, uneven skin tone, and signs of photoaging.
6. Contact Us for Delentigo™ Ingredient Consultation
✔ 3H Cosmetic supplies cosmetic ingredients and provides formulation consultation, technical documentation, and samples to support customers in product development.
☎ Hotline: 032 761 2525
