EXO-ALOSOME™

* PRODUCT NAME:
• EXO-ALOSOME™

* INCI NAME:
• Water, Glycerin, 1,2-Hexanediol, Aloe Barbadensis Leaf Extract

* PACKING:
• 1kg, 5kg, 10kg, 20kg

* ORIGIN:
• Korea

* APPEARANCE: Clear liquid, colorless to pale yellow.

1. ALOE EXOSOME – ACTIVATING MOISTURE RETENTION & SKIN PROTECTION AT THE CELLULAR LEVEL
• In the new generation of biotech cosmetics, plant-derived exosomes are emerging as a key technological platform due to their superior ability to deliver cellular signals and active compounds at the cellular level.
• EXO-ALOSOME™ is an aloe-derived exosome extracted from Aloe vera using ultra-high pressure technology, preserving the full spectrum of valuable polysaccharides and phytochemicals found in aloe gel.
• Aloe vera is widely recognized for:
✔ High polysaccharide content
✔ Exceptional water-retention capacity
✔ Natural soothing properties
✔ Support for damaged skin recovery
• When delivered in exosome form, these bioactive compounds are transported more efficiently, enhancing their biological impact on the skin.

2. EXOSOME – THE “BIOLOGICAL MESSENGER” OF THE SKIN
• Exosomes are nano-sized extracellular vesicles (30–200 nm) secreted by cells, functioning as biological communication systems between cells.
• With their nano-scale size (<200 nm) and high biocompatibility, exosomes are capable of:
✔ Enhancing intercellular communication
✔ Promoting natural recovery mechanisms
✔ Optimizing the efficacy of delivered active ingredients
• When combined with polysaccharide-rich botanicals such as Aloe vera, exosomes not only act as carriers but also enhance moisture delivery and biological signaling deep into the epidermis.
→ This is the core technology behind EXO-ALOSOME™ – a next-generation biological hydration and skin barrier reinforcement solution.

3. EXTRACTION TECHNOLOGY – ENSURING NANO PARTICLE STABILITY
• EXO-ALOSOME™ is produced using ultra-high pressure technology (10–1000 MPa), which enables:
✔ Disruption of aloe cell wall structures
✔ Release of natural exosomes
✔ Purification and collection of particles <200 nm
✔ Particle size and concentration analysis via NTA (Nanoparticle Tracking Analysis)

• ANALYTICAL RESULTS:
✔ Average particle size: 190.0 nm
✔ Concentration: 4.15 × 10⁸ ± 1.24 × 10⁶ particles/mL
• The uniform nano-size distribution helps to:
→ Enhance epidermal penetration
→ Improve biological moisture retention efficiency
→ Maintain stability in cosmetic formulations
Therefore, EXO-ALOSOME™ is not merely a conventional aloe extract, but an advanced biological polysaccharide delivery system.

4. PROVEN BIOLOGICAL EFFICACY
4.1 SOOTHING EFFECT
• In heat-stressed HaCaT cell models, EXO-ALOSOME™ demonstrated:
→ Strong inhibition of PAR-2
→ Reduction of inflammatory responses
→ Support for irritated skin soothing
• This mechanism is particularly important in formulations designed for sensitive and post-treatment skin recovery.

4.2 SKIN BARRIER ENHANCEMENT & HYDRATION
• Studies on HaCaT cells showed:
→ Increased expression of Aquaporin-3 (AQP3)
→ Improved intracellular water transport
→ Support for moisture retention and skin barrier reinforcement
• This mechanism makes EXO-ALOSOME™ an ideal ingredient for intensive hydration and dehydrated skin recovery formulations.

5. WHY CHOOSE PLANT-DERIVED EXOSOMES?
• Compared to human- or animal-derived exosomes, plant exosomes offer significant advantages:
✔ HIGH SAFETY & BIOCOMPATIBILITY
✔ NO SOURCE-RELATED CONCERNS
✔ ALIGNED WITH CLEAN BEAUTY & SUSTAINABLE TRENDS
✔ SUITABLE FOR LARGE-SCALE PRODUCTION
→ EXO-ALOSOME™ is an ideal solution for brands developing advanced hydration, soothing, and skin barrier reinforcement product lines based on modern biotechnology.