KTP1-Filagreen
* PRODUCT NAME:
β’ ππππ-π
π’π₯ππ π«πππ§
* INCI NAME:
β’ sr-(Methionyl sh-Oligopeptide-194 Methionyl sh-Polypeptide-170)
* PACKING:
β’ 1kg/5kg/10kg/20kg
* ORIGIN:
β’ KOREA
* INTRODUCTION:
β’ ππππ-π
π’π₯ππ π«πππ§Β is a pioneering filaggrin-based ingredient developed by CoseedBiopharm β the first company to successfully create a cosmetic-grade filaggrin ingredient for skin and the first to register Filaggrin as a cosmetic raw material on the PCPC (INCI) system.
This ingredient directly targets keratinocytes, the core cells of the stratum corneum, enhancing the skinβs natural strength, reinforcing the cornified structure, and improving moisture retention.
Unlike conventional barrier-repair ingredients that focus mainly on ceramide, ππππ-π
π’π₯ππ π«πππ§Β addresses the biological root of skin weaknessβrebuilding the βbricksβ (keratinocytes) themselves rather than only βsealingβ moisture like traditional products.
β’ ππππ-π
π’π₯ππ π«πππ§ is especially suitable for sensitive or compromised skin, including:
+ Atopic Dermatitis: strengthens the barrier, reduces irritation, dryness, and itching.
+ Psoriasis: supports stratum corneum regeneration, evens skin tone, and reduces flaking.
+ Ichthyosis: softens the skin, boosts moisture retention, and improves cornified structure.
+ Post-peel, laser, or microneedling skin: accelerates recovery, reduces redness and sensitivity.
β’ Thanks to its deep penetration powered by KTP-Liposome technology, ππππ-π
π’π₯ππ π«πππ§Β delivers comprehensive barrier restorationβtransitioning from βtemporary moisture lockingβ to true reconstruction of the stratum corneum from within, opening a new direction for advanced, high-performance skincare formulations.
β’ ππππ-π
π’π₯ππ π«πππ§ – is a milky white liquid ingredient protected by exclusive patents.
* MECHANISM OF ACTION:
β’ Filagreen in ππππ-π
π’π₯ππ π«πππ§ acts as the βbricksβ of the stratum corneum, connecting keratin fibers to make the outermost layer solid, even, and structurally stable.
β’ Meanwhile, ceramide functions as the βmortar,β bonding the bricks together, maintaining the lipid barrier, and locking in moisture. ππππ-π
π’π₯ππ π«πππ§ + ceramide form a resilient skin wall that not only retains moisture but also reduces irritation and enhances resistance against environmental aggressors. Without one of these components, the skin wall becomes weak, dry, irritated, or inflamed.
=> This means KTP1-Filagreen not only rebuilds the βbricksβ but also restores the skinβs natural defense mechanism internally, offering long-lasting and sustainable benefits.
β’ The KTP system helps deliver hydrophilic molecules, such as proteins and peptides, into the stratum corneum by overcoming the skinβs naturally hydrophobic surface, enabling more efficient penetration.
* EFFICACY:
1. Strengthens the Skin Barrier in Atopic Dermatitis Model
=> Use of ππππ-π π’π₯ππ π«πππ§Β increases filaggrin expression by 49.85% compared to the stimulated group.
2. Promotes Keratinocyte Proliferation
=> At a maximum concentration of 10 mg/ml, ππππ-π π’π₯ππ π«πππ§Β increases keratinocyte proliferation by 198% compared to the control group, demonstrating its ability to support epidermal regeneration and strengthen the barrier.
3. Accelerates Wound Healing
=> At 10 Β΅g/ml, KTP1-Filagreen boosts wound-healing activity by 91% compared to control, showcasing its role in helping weakened, sensitive, or post-treatment skin recover rapidly.
4. Increases NMF (Natural Moisturizing Factor)
=> ππππ-π
π’π₯ππ π«πππ§ increases Caspase-14 expression by 102% compared to the stimulated group.
Caspase-14 is a key enzyme in keratinocytes that synthesizes NMF, helping maintain hydration and strengthening the skin barrier.
5. Superior Penetration Ability
=> ππππ-π π’π₯ππ π«πππ§ demonstrates a 72% increase in penetration compared to standard Filagreen without KTP attachment.
* CONCLUSION:
β’ ππππ-π
π’π₯ππ π«πππ§ is not just another barrier-repair ingredientβit is a breakthrough in skin barrier regeneration. By supplementing filaggrin, the key structural protein that determines the strength of the stratum corneum, this ingredient provides a holistic solution: boosting natural moisture, reinforcing barrier structure, improving elasticity, and effectively restoring sensitive, dehydrated, or damaged skin.
β’ ππππ-π π’π₯ππ π«πππ§ represents the future of sustainable skin barrier restoration in modern cosmetics, offering brands a powerful opportunity to formulate products that are truly differentiated and deliver long-lasting, visible results for users.
