Exo-CicaSome
* PRODUCT NAME
* INCI NAME:
• Water, Glycerin, 1,2-Hexanediol, Centella Asiatica Leaf Extract
* PACKING:
• 1kg, 5kg, 10kg, 20kg
* ORIGIN:
• Hàn Quốc
* APPEARANCE:
• Colorless ~ Pale yellow transparent liquid
1. EXO-CICASOME – Centella Exosome: A Next-Generation Solution for Strengthening the Skin Barrier & Soothing the Skin
• With the growing trend of biotech skincare, exosomes are emerging as an advanced technology due to their ability to transmit signals and deliver active substances directly to skin cells.
• EXO-CICASOME is a Centella-derived exosome ingredient extracted using ultra-high-pressure technology, enabling the collection of nano-sized particles carrying plant-derived bioactive compounds with high purity and efficacy.
• As a result, the product not only provides moisturizing and soothing benefits, but also helps optimize the penetration and activity of active ingredients on the skin.
2. Plant Exosome Extraction Technology
✔ EXO-CICASOME is produced using ultra-high-pressure technology (10–1000 MPa), which helps to:
• Break down plant cell wall structures
• Release natural exosomes
• Purify nano-sized particles smaller than 200 nm
• Control particle size and concentration using Nanoparticle Tracking Analysis (NTA)
• This technology enables the collection of plant-derived exosomes with high stability and biological activity, making them suitable for advanced cosmetic formulations.
3. Nano-Particle Structure Analysis of EXO-CICASOME
✔ Analysis using NTA (Nanoparticle Tracking Analysis) showed:
• Average particle size: 143.8 nm
• Particle concentration: 8.08 × 10¹⁰ ± 9.20 × 10⁹ particles/mL
✔ The uniform nano-sized particles help to:
• Enhance penetration through the epidermis
• Improve active ingredient delivery
• Enhance the biological efficacy of tea tree on the skin
4. Scientifically Demonstrated Biological Efficacy
4.1 Skin Calming Effect
✔ In a heat-stressed HaCaT cell model, tea tree-derived exosomes showed the ability to
• Strongly inhibit PAR-2
• Reduce inflammatory responses
• Support skin soothing and help reduce irritation
4.2 Skin Barrier Strengthening Effect
✔ At a concentration of 5%, EXO-CICASOME increased Filaggrin (FLG) expression by 75.43% and Aquaporin-3 (AQP3) expression by 67.47% compared with the control group, thereby helping maintain skin barrier function.
4.3 Moisturizing Effect
✔ EXO-CICASOME helps increase Aquaporin-3 expression in HaCaT cells, thereby supporting the skin’s ability to maintain hydration.
5. Emerging Trend: Plant-Derived Exosomes in Cosmetics
✔ Compared with exosomes derived from humans or animals, plant-derived exosomes offer several advantages:
• High safety and biocompatibility
• Fewer concerns regarding biological origin
• Easy scalability for large-scale production
• Aligned with Clean Beauty & Sustainable Beauty trends
✔ Thanks to these advantages, EXO-CICASOME is an ideal solution for skincare formulations.
📌 Contact 3H Cosmetic for consultation on incorporating EXO-CICASOME into your cosmetic formulations.
